Supplement Insider Evidence-based wellness
Ingredients/Alpha lipoic acid
Moderate evidence overall reviewed 16 Sep 2026

Alpha lipoic acid

A naturally occurring antioxidant used clinically in Europe for diabetic neuropathy

The nerve-support ingredient with the most research, mostly in a population — people with diabetic nerve pain — that most buyers of general "nerve health" supplements don't belong to.

What the evidence supports

Moderate Diabetic peripheral neuropathy IV formulations have the strongest data; oral trials show more modest symptom improvement over weeks to months.
Limited Nerve support in non-diabetic adults Little direct trial evidence for general "nerve health" outside diagnosed neuropathy.
Dose used in trials
600 mg

per day orally, in most neuropathy trials; higher IV doses were used in a clinical setting, not comparable to a capsule.

Safety
Generally tolerated

Can lower blood glucose; GI upset at higher doses.

Ask a doctor first if
On glucose meds

Combined glucose-lowering effects can cause hypoglycaemia in some people.

Related reading

Nerve health
The full nerve-health evidence guide
Product review
Neuralisse pairs ALA with benfotiamine